Gelatin capsules play an important role in the pharmaceutical industry. It is preferred for its versatility and transparency in elastic form, its ability to melt at body temperature, and its thermally reversible flexibility. Soft gelatin is widely demanded due to its non-allergic properties, safety and non-toxicity. In addition, the proteins that make up the gelatin make the capsules easy to digest and easy to swallow.
But even compared to its countless benefits, gelatin as a material is very sensitive to moisture and temperature. Moisture can damage the capsules and complicate the entire manufacturing process. In the presence of high humidity, the capsules easily become brittle, melt and show resistance to hardening in the form of bands. In severe cases, high relative humidity (RH) can lead to unwanted microbial contamination, which always reduces the quality of capsules.
This requires careful control of the air entering the dryer throughout the production and drying process. The air must be carefully conditioned to achieve acceptable levels of temperature and humidity. The threat of moisture can be understood through the manufacturing process. In this process, warm liquid gelatin is spread over a slowly rotating stainless steel drum, and then freeze-drying air is introduced to coagulate the gelatin into a sticky elastic band. In this process, a thin strip is automatically formed into a drug-filled capsule. During the whole process, if the temperature and humidity exceed unacceptable levels, the soft gelatin cannot be cured and remains soft. In turn, soft wet capsules are transferred from the encapsulation machine to a tumble dryer or kiln for rapid drying.
Great care must be taken not only during the production process, but also when transporting hygroscopic materials from the storage area to the processing area. The transfer must be carried out under dry conditions to prevent re-wetting of the capsules during the filling and packaging operations. Considering the variety of requirements that must be met, dehumidifier dehumidification solutions are the ideal technology to effectively meet the most complex and stringent humidity/humidity control requirements in the capsule manufacturing process. Advanced technology ensures optimal humidity levels with extremely low dew points throughout all stages of production, storage and transport. It acts to protect raw materials from moisture threats and also ensures the highest sanitary conditions throughout the year, regardless of the environment.
In addition to production, even storage requires low humidity conditions to avoid any revival conditions that could undermine all product manufacturing efforts. Therefore, the packaging of gelatin capsules is made in aluminum foil storage, which provides a humidity-controlled environment for moisture-sensitive capsules.
Given that the quality of gelatin capsules is critical to human well-being, medicines must be produced with the goal of improving human health. Therefore, dehumidification solutions must be installed in the production infrastructure of gelatin capsules.
Post time: Nov-09-2022
