APPLICATION OF GELATIN IN BIOMEDICAL MATERIALS
Gelatin, a natural biopolymer material, is a food additive prepared by moderate hydrolysis of animal bones, skins, tendons, tendons and scales. There is nothing comparable to this kind of biomedical materials in gelatin, because of its biodegradability, good biocompatibility, gel and low cost. Therefore, gelatin has been widely used as a traditional pharmaceutical excipient in biomedical materials.
Blood Substitutes
Blood transfusion is necessary in many cases, such as partial surgery or acute massive hemorrhage. However, the shortage of blood source, the relatively complicated blood configuration, and the risk of allogeneic blood supply also hinder the timeliness, effectiveness and safety of clinical treatment to a great extent. The method of plasma substitution can solve these problems, so it has great clinical application potential and technical improvement space. Therefore, gelatin materials, such as succinyl gelatin and polygelatin peptide, are widely used as plasma substitutes in clinic. Gelatin plasma substitutes will be used in emergencies such as decreased blood volume and shock. Colloid penetration can expand blood volume and improve microcirculation. Gelatin blood substitutes have many advantages, such as degradability, large input, non-toxic, non immunogenicity and so on.
Hemostatic Materials
In recent years, the medical community has paid more attention to the development of new hemostatic materials. Absorbable gelatin sponge has attracted much attention because it has the advantages of good hemostatic effect, low price and strong processability. The hemostatic mechanism of gelatin hemostatic sponge is mainly to produce reticular structure by blocking blood vessels, so as to agglutinate platelets and deposit fibrinogen. This is very beneficial to the formation of thrombosis, so as to reduce the coagulation time and finally stop bleeding. According to its coagulation mechanism, gelatin hemostatic sponge has the key functions of mechanical compression and water absorption. In the whole coagulation process, for example, it does not play a significant role in promoting the generation of important hemostatic processes such as prothrombin activation. The common absorbent gelatin sponge used in clinic has many disadvantages, such as large reaction of tissue foreign bodies, low hemostatic efficiency and easy falling off. At present, gelatin is often modified or compounded with other materials to produce hemostatic materials with relatively good performance.
Other Applications
Gelatin mainly comes from collagen in body tissues, so it has very outstanding biological properties, such as good biocompatibility and biodegradability, so it has been widely used in biomedical field. Gelatin can be used not only in the above aspects, but also in the treatment of skin diseases. For example, hydrolyzed gelatin can treat chapped skin, ichthyosis and dandruff. Moreover, gelatin has also been widely used in internal medicine. In the Chinese Pharmacopoeia, it is described that macromolecular gelatin has the effects of moistening dryness and generating blood, and has certain curative effects on many symptoms such as anemia and blood loss. Hydrolyzed gelatin also has a very obvious effect in the treatment of chronic gastritis and other symptoms.
Post time: Aug-11-2021
